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J Affect Disord. 2015 Nov 1;186:186-91. doi: 10.1016/j.jad.2015.06.051. Epub 2015 Jul 29.

Effect of electroconvulsive therapy on gray matter volume in major depressive disorder.

Author information

1
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan. Electronic address: ota@ncnp.go.jp.
2
Department of Psychiatry, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.
3
Department of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.
4
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan.

Abstract

BACKGROUND:

Although the clinical efficacy of electroconvulsive therapy (ECT) is well established, the underlying mechanisms of action remain elusive. The aim of this study was to elucidate structural changes of the brain following ECT in patients with major depressive disorder (MDD).

METHOD:

Fifteen patients with MDD underwent magnetic resonance imaging scanning before and after ECT. Their gray matter volumes were compared between pre- and post-ECT.

RESULTS:

There were significant volume increases after ECT in the bilateral medial temporal cortices, inferior temporal cortices, and right anterior cingulate. Further, the increase ratio was correlated with the clinical improvement measured by the Hamilton Depression Rating scale.

LIMITATION:

All subjects were treated with antidepressants that could have a neurotoxic or neuroprotective effect on the brain.

CONCLUSIONS:

We found that there were significant increases of gray matter volume in medial temporal lobes following ECT, suggesting that a neurotrophic effect of ECT could play a role in its therapeutic effect.

KEYWORDS:

Amygdala; Electroconvulsive therapy; Hippocampus; Major depressive disorder

PMID:
26247910
DOI:
10.1016/j.jad.2015.06.051
[Indexed for MEDLINE]

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