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J Int Med Res. 2015 Oct;43(5):599-609. doi: 10.1177/0300060515583076. Epub 2015 Aug 5.

Diagnostic value of serum CA125, CA19-9 and CA15-3 in endometriosis: A meta-analysis.

Author information

1
Department of Obstetrics and Gynaecology, The Third Affiliated Hospital, Zhengzhou University, Henan, China shenairzhzh@126.com.
2
Department of Obstetrics and Gynaecology, The Third Affiliated Hospital, Zhengzhou University, Henan, China.

Abstract

AIM:

To evaluate the diagnostic value of serum cancer antigen (CA)125, CA19-9 and CA15-3 concentrations in endometriosis.

METHODS:

Case-control studies evaluating CA125, CA19-9 and CA15-3 and endometriosis, published between January 2000 and November 2014 were retrieved from PubMed(®) and Google Scholar. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated. Subgroup analyses were carried out by ethnicity and disease stage (early, stage I/II; advanced, stage III/IV).

RESULTS:

The analysis included 12 case-control studies (963 cases, 855 controls). CA125 was associated with endometriosis in the overall population (SMD 0.82, 95% CI 0.72, 0.92), Caucasian subgroup (SMD 1.08, 95% CI 0.96, 1.19), and early (SMD 1.20, 95% CI 0.93, 1.48) or advanced disease (SMD 1.29, 95% CI 1.04, 1.55). CA19-9 was associated with endometriosis in the overall population (SMD 0.48, 95% CI 0.24, 0.72), Caucasian subgroup (SMD 0.31, 95% CI 0.07, 0.55), Asian subgroup (SMD 9.65, 95% CI 7.88, 11.42) and advanced disease (SMD 0.60, 95% CI 0.34, 0.87). CA15-3 was significantly associated with advanced disease (SMD 0.47, 95% CI 0.09, 0.84).

CONCLUSIONS:

Serum CA125 and CA19-9 may represent useful biomarkers for the noninvasive diagnosis of endometriosis.

KEYWORDS:

CA125; CA15-3; CA19-9; endometriosis; meta-analysis

PMID:
26246541
DOI:
10.1177/0300060515583076
[Indexed for MEDLINE]

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