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J Agric Food Chem. 2015 Sep 9;63(35):7765-74. doi: 10.1021/acs.jafc.5b02801. Epub 2015 Aug 21.

Long-Term Regulation of the Local Renin-Angiotensin System in the Myocardium of Spontaneously Hypertensive Rats by Feeding Bioactive Peptides Derived from Spirulina platensis.

Pan H1,2, She X1, Wu H1, Ma J1, Ren D1, Lu J2.

Author information

1
Beijing Key Laboratory of Forest Food Process and Safety, Department of Food Science and Engineering, College of Biological Sciences and Technology, Beijing Forestry University , Beijing 100083, People's Republic of China.
2
Beijing Engineering Research Center of Protein & Functional Peptides, China National Research Institute of Food & Fermentation Industries , Beijing 100015, People's Republic of China.

Abstract

This study investigated the long-term (8 weeks) anti-hypertensive effects of 10 mg/kg tripeptides isolated from Spirulina platensis, Ile-Gln-Pro (IQP) and Val-Glu-Pro (VEP), and S. platensis hydrolysates (SH) on spontaneously hypertensive rats. The treatment period was 6 weeks, and observation continued for another 2 weeks. After treatment, weighted systolic blood pressure, weighted diastolic blood pressure, left ventricular mass index, and right ventricular mass index of groups treated with IQP, VEP, and SH were significantly lower than those of the group treated with distilled water, even when the treatments had been withdrawn for 2 weeks. Quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay, and Western blotting showed the mRNA expression levels and protein/peptide concentrations of the main components of the renin angiotensin system in myocardium were significantly affected by treatment: angiotensin converting enzyme, angiotensin II, and angiotensin type 1 receptor were down-regulated, whereas angiotensin type 2 receptor, angiotensin converting enzyme 2, angiotensin-(1-7), and Mas receptor were up-regulated.

KEYWORDS:

Ile-Gln-Pro; Spirulina platensis hydrolysates; Val-Glu-Pro; hypertension; myocardium; renin angiotensin system

PMID:
26245714
DOI:
10.1021/acs.jafc.5b02801
[Indexed for MEDLINE]

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