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Cell Metab. 2015 Aug 4;22(2):200-1. doi: 10.1016/j.cmet.2015.07.017.

NNMT: A Bad Actor in Fat Makes Good in Liver.

Author information

1
Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
2
Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Obesity Research & Education Initiative, Carver College of Medicine, University of Iowa, Iowa City, IA 52242. Electronic address: charles-brenner@uiowa.edu.

Abstract

High adipose expression of NNMT, an enzyme that converts nicotinamide to 1-methyl-nicotinamide, correlates with adiposity. Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.

PMID:
26244929
PMCID:
PMC4768475
DOI:
10.1016/j.cmet.2015.07.017
[Indexed for MEDLINE]
Free PMC Article

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