Format

Send to

Choose Destination
FASEB J. 2015 Dec;29(12):4783-93. doi: 10.1096/fj.15-277731. Epub 2015 Aug 4.

Microgram amounts of abscisic acid in fruit extracts improve glucose tolerance and reduce insulinemia in rats and in humans.

Author information

1
*Department of Experimental Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research, and Department of Internal Medicine, University of Genoa, Genoa, Italy; and Animal Facility, Istituto di Ricovero e Cura a Carattere Scientifico, Azienda Ospedaliera Universitaria San Martino, Istituto Scientifico Tumori, Genoa, Italy mirko.magnone@unige.it ezocchi@unige.it.
2
*Department of Experimental Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research, and Department of Internal Medicine, University of Genoa, Genoa, Italy; and Animal Facility, Istituto di Ricovero e Cura a Carattere Scientifico, Azienda Ospedaliera Universitaria San Martino, Istituto Scientifico Tumori, Genoa, Italy.

Abstract

2-Cis,4-trans-abscisic acid (ABA) is a plant hormone that is present also in animals. Several lines of evidence suggest that ABA contributes to the regulation of glycemia in mammals: nanomolar ABA stimulates insulin release from β-pancreatic cells and glucose transporter-4-mediated glucose uptake by myoblasts and adipocytes in vitro; plasma ABA increases in normal human subjects, but not in diabetic patients, after a glucose load for an oral glucose tolerance test (OGTT). The presence of ABA in fruits prompted an exploration of the bioavailability of dietary ABA and the effect of ABA-rich fruit extracts on glucose tolerance. Rats underwent an OGTT, with or without 1 µg/kg ABA, either synthetic or present in a fruit extract. Human volunteers underwent an OGTT or a standard breakfast and lunch, with or without a fruit extract, yielding an ABA dose of 0.85 or 0.5 µg/kg, respectively. Plasma glucose, insulin, and ABA were measured at different time points. Oral ABA at 0.5-1 µg/kg significantly lowered glycemia and insulinemia in rats and in humans. Thus, the glycemia-lowering effect of low-dose ABA in vivo does not depend on an increased insulin release. Low-dose ABA intake may be proposed as an aid to improving glucose tolerance in patients with diabetes who are deficient in or resistant to insulin.

KEYWORDS:

OGTT; apricots; plasma glucose; plasma insulin; standard B&L

PMID:
26243865
DOI:
10.1096/fj.15-277731
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center