Format

Send to

Choose Destination
Cytokine. 2015 Oct;75(2):338-43. doi: 10.1016/j.cyto.2015.07.021. Epub 2015 Aug 1.

The adipokine preadipocyte factor-1 is downregulated in preeclampsia and expressed in placenta.

Author information

1
University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany.
2
University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany. Electronic address: Ulrike.Wurst@medizin.uni-leipzig.de.
3
University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
4
Centre for Trophoblast Research, Medical School, Wayne State University, Detroit, MI, USA.
5
University of Leipzig, Institute of Laboratory Medicine, 04103 Leipzig, Germany.
6
University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany.

Abstract

BACKGROUND:

Adipokines contribute to the development of preeclampsia (PE), a severe pregnancy complication which increases the future risk for cardiovascular and metabolic disease in both mother and newborn. Pre-adipocyte factor-1 (Pref-1) was recently introduced as a novel antiangiogenic and antiadipogenic adipokine.

MATERIAL AND METHODS:

Pref-1 was quantified in patients with PE (n=51) and healthy pregnant controls (n=51) during pregnancy, as well as 6 months after delivery (study population 1). Furthermore, Pref-1 was investigated in the immediate peripartal period and the placenta in 40 healthy pregnant women undergoing elective cesarean section (study population 2).

RESULTS:

In study population 1, median Pref-1 serum concentrations during pregnancy were significantly lower in women with PE (0.5 μg/l) as compared to healthy pregnant controls (0.7 μg/l) (p<0.001). Furthermore, Pref-1 serum concentrations were independently predicted by PE, leptin levels, and gestational age in this population. In both study populations, Pref-1 serum levels significantly decreased after delivery as compared to prepartal levels. Moreover, significant expression of Pref-1 was detected in placental tissue.

CONCLUSION:

Maternal Pref-1 serum concentrations are significantly decreased in PE. The pathophysiological significance of this regulation needs to be studied in more detail in future experiments.

KEYWORDS:

Adipogenesis; Cesarean section; Placenta; Preeclampsia; Pref-1

PMID:
26242929
DOI:
10.1016/j.cyto.2015.07.021
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center