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Neurobiol Aging. 2015 Oct;36(10):2885-92. doi: 10.1016/j.neurobiolaging.2015.06.022. Epub 2015 Jun 24.

Therapeutic potentials of human adipose-derived stem cells on the mouse model of Parkinson's disease.

Author information

1
Research Division, Department of Structure and Function of Neural Network, Korea Brain Research Institute, Daegu, Korea.
2
Research Division, Department of Neural Development and Disease, Korea Brain Research Institute, Daegu, Korea.
3
Neuroscience Research Institute, Gachon University, Incheon, Korea.
4
K-STEM CELL Institute, Seoul, Korea.
5
Neuroscience Research Institute, Gachon University, Incheon, Korea; Department of Pharmacology, Gachon University, Incheon, Korea. Electronic address: keuna705@gachon.ac.kr.
6
Department of Pharmacology, Gachon University, Incheon, Korea; Korea Brain Research Institute, Daegu, Korea; Department of Pharmacology, Seoul National University Medical College, Seoul, Korea. Electronic address: yhsuh@snu.ac.kr.

Abstract

The treatment of Parkinson's disease (PD) using stem cells has long been the focus of many researchers, but the ideal therapeutic strategy has not yet been developed. The consistency and high reliability of the experimental results confirmed by animal models are considered to be a critical factor in the stability of stem cell transplantation for PD. Therefore, the aim of this study was to investigate the preventive and therapeutic potential of human adipose-derived stem cells (hASC) for PD and was to identify the related factors to this therapeutic effect. The hASC were intravenously injected into the tail vein of a PD mouse model induced by 6-hydroxydopamine. Consequently, the behavioral performances were significantly improved at 3 weeks after the injection of hASC. Additionally, dopaminergic neurons were rescued, the number of structure-modified mitochondria was decreased, and mitochondrial complex I activity was restored in the brains of the hASC-injected PD mouse model. Overall, this study underscores that intravenously transplanted hASC may have therapeutic potential for PD by recovering mitochondrial functions.

KEYWORDS:

6-OHDA; Human adipose-derived stem cells; Mitochondria; Parkinson's disease

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