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J Agric Food Chem. 2015 Sep 9;63(35):7760-4. doi: 10.1021/acs.jafc.5b02766. Epub 2015 Aug 19.

Anti-Glycation Effects of Pomegranate (Punica granatum L.) Fruit Extract and Its Components in Vivo and in Vitro.

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Department of Pharmaceutial and Health Sciences, Faculty of Pharmaceutical Sciences, Josai University , Saitama, Japan.
Morishita Jintan Co., Ltd. , Osaka, Japan.


Accumulation of advanced glycation end products (AGEs) leads to various diseases such as diabetic complications and arteriosclerosis. In this study, we examined the effect of pomegranate fruit extract (PFE) and its constituent polyphenols on AGE formation in vivo and in vitro. PFE, fed with a high-fat and high-sucrose (HFS) diet to KK-A(y) mice, significantly reduced glycation products such as glycoalbumin (22.0 ± 2.4%), hemoglobin A1c (5.84 ± 0.23%), and serum AGEs (8.22 ± 0.17 μg/mL), as compared to a control HFS group (30.6 ± 2.6%, 7.45 ± 0.12%, and 9.55 ± 0.17 μg/mL, respectively, P < 0.05). In antiglycation assays, PFE, punicalin, punicalagin, ellagic acid, and gallic acid suppressed the formation of AGEs from bovine serum albumin and sugars. In this study, we discuss the mechanism of the antiglycation effects of PFE and its components in vivo and in vitro.


advanced glycation end products (AGEs); diabetes; ellagic acid; pomegranate; punicalagin

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