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FEMS Yeast Res. 2015 Nov;15(7). pii: fov071. doi: 10.1093/femsyr/fov071. Epub 2015 Aug 4.

Essential metals at the host-pathogen interface: nutritional immunity and micronutrient assimilation by human fungal pathogens.

Author information

1
Aberdeen Fungal Group, School of Medical Sciences, Aberdeen AB25 2ZD, UK.
2
Aberdeen Fungal Group, School of Medical Sciences, Aberdeen AB25 2ZD, UK Duncan.Wilson@abdn.ac.uk.

Abstract

The ability of pathogenic microorganisms to assimilate sufficient nutrients for growth within their hosts is a fundamental requirement for pathogenicity. However, certain trace nutrients, including iron, zinc and manganese, are actively withheld from invading pathogens in a process called nutritional immunity. Therefore, successful pathogenic species must have evolved specialized mechanisms in order to adapt to the nutritionally restrictive environment of the host and cause disease. In this review, we discuss recent advances which have been made in our understanding of fungal iron and zinc acquisition strategies and nutritional immunity against fungal infections, and explore the mechanisms of micronutrient uptake by human pathogenic fungi.

KEYWORDS:

fungal pathogenicity; host–pathogen interactions; iron; zinc

PMID:
26242402
PMCID:
PMC4629794
DOI:
10.1093/femsyr/fov071
[Indexed for MEDLINE]
Free PMC Article

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