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Pathog Dis. 2015 Oct;73(7). pii: ftv055. doi: 10.1093/femspd/ftv055. Epub 2015 Aug 4.

Bordetella pertussis, B. parapertussis, vaccines and cycles of whooping cough.

Author information

1
Institut Pasteur, Molecular Prevention and Therapy of Human Infections Unit, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France CNRS URA-3012, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France valerie.bouchez@pasteur.fr.
2
Institut Pasteur, Molecular Prevention and Therapy of Human Infections Unit, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France CNRS URA-3012, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France.

Abstract

Whooping cough is a vaccine-preventable disease due to Bordetella pertussis and B. parapertussis. This highly contagious respiratory disease occurs through epidemic cycles every 3-5 years and vaccination did not change this frequency. Models suggest that the cyclic increase of susceptibles is linked to demographic differences and different vaccine coverage. However, differences in surveillance of the disease as well as adaptation of the agents of the disease to their human hosts and to vaccine pressure might also play an important role. These parameters are discussed in this review.

KEYWORDS:

Bordetella parapertussis; Bordetella pertussis; polymorphism; vaccine; whooping cough

PMID:
26242280
DOI:
10.1093/femspd/ftv055
[Indexed for MEDLINE]

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