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Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10521-6. doi: 10.1073/pnas.1508785112. Epub 2015 Aug 3.

Local generation of multineuronal spike sequences in the hippocampal CA1 region.

Author information

1
NYU Neuroscience Institute, School of Medicine, New York University, New York, NY 10016; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, 69978 Tel Aviv, Israel Gyorgy.Buzsaki@nyumc.org eranstark@gmail.com.
2
NYU Neuroscience Institute, School of Medicine, New York University, New York, NY 10016;
3
NYU Neuroscience Institute, School of Medicine, New York University, New York, NY 10016; Gyorgy.Buzsaki@nyumc.org eranstark@gmail.com.

Abstract

Sequential activity of multineuronal spiking can be observed during theta and high-frequency ripple oscillations in the hippocampal CA1 region and is linked to experience, but the mechanisms underlying such sequences are unknown. We compared multineuronal spiking during theta oscillations, spontaneous ripples, and focal optically induced high-frequency oscillations ("synthetic" ripples) in freely moving mice. Firing rates and rate modulations of individual neurons, and multineuronal sequences of pyramidal cell and interneuron spiking, were correlated during theta oscillations, spontaneous ripples, and synthetic ripples. Interneuron spiking was crucial for sequence consistency. These results suggest that participation of single neurons and their sequential order in population events are not strictly determined by extrinsic inputs but also influenced by local-circuit properties, including synapses between local neurons and single-neuron biophysics.

KEYWORDS:

hippocampus; mouse; optogenetics; ripples; temporal precision

PMID:
26240336
PMCID:
PMC4547251
DOI:
10.1073/pnas.1508785112
[Indexed for MEDLINE]
Free PMC Article

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