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Brain Res. 2016 May 1;1638(Pt A):88-96. doi: 10.1016/j.brainres.2015.06.053. Epub 2015 Jul 31.

Regenerative cellular therapies for neurologic diseases.

Author information

1
Department of Neurology, Johns Hopkins University, Baltimore, MD, United States. Electronic address: mlevy@jhmi.edu.
2
Department of Neurosurgery, Emory University, Atlanta, GA, United States.
3
Center for Regenerative Medicine, National Institutes of Health, Bethesda, MD, United States.
4
Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States. Electronic address: Clive.Svendsen@cshs.org.

Abstract

The promise of stem cell regeneration has been the hope of many neurologic patients with permanent damage to the central nervous system. There are hundreds of stem cell trials worldwide intending to test the regenerative capacity of stem cells in various neurological conditions from Parkinson's disease to multiple sclerosis. Although no stem cell therapy is clinically approved for use in any human disease indication, patients are seeking out trials and asking clinicians for guidance. This review summarizes the current state of regenerative stem cell transplantation divided into seven conditions for which trials are currently active: demyelinating diseases/spinal cord injury, amyotrophic lateral sclerosis, stroke, Parkinson's disease, Huntington's disease, macular degeneration and peripheral nerve diseases. This article is part of a Special Issue entitled SI: PSC and the brain.

KEYWORDS:

Neurologic disease; Regeneration; Stem cell

PMID:
26239912
PMCID:
PMC4733583
DOI:
10.1016/j.brainres.2015.06.053
[Indexed for MEDLINE]
Free PMC Article

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