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Hepatology. 2015 Dec;62(6):1893-908. doi: 10.1002/hep.28025. Epub 2015 Oct 27.

Present and future therapies of hepatitis B: From discovery to cure.

Author information

1
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
2
Baruch S. Blumberg Institute, Doylestown, PA.
3
National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK.
4
Department of Infectious Diseases, Molecular Virology and German Center for Infection Diseases, University Hospital Heidelberg, Heidelberg, Germany.
5
Hepatology Department, Lyon University and Cancer Research Center of Lyon, INSERM U1052, Lyon, France.
6
Victorian Infectious Diseases Reference Laboratory, Doherty Institute, Melbourne, VIC, Australia.
7
Department of Medicine, Philadelphia Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
8
Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI.

Abstract

Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million people worldwide. While treatment for HBV has improved, HBV patients often require lifelong therapies and cure is still a challenging goal. Recent advances in technologies and pharmaceutical sciences have heralded a new horizon of innovative therapeutic approaches that are bringing us closer to the possibility of a functional cure of chronic HBV infection. In this article, we review the current state of science in HBV therapy and highlight new and exciting therapeutic strategies spurred by recent scientific advances. Some of these therapies have already entered into clinical phase, and we will likely see more of them moving along the development pipeline.

CONCLUSION:

With growing interest in developing and efforts to develop more effective therapies for HBV, the challenging goal of a cure may be well within reach in the near future.

PMID:
26239691
PMCID:
PMC4681668
DOI:
10.1002/hep.28025
[Indexed for MEDLINE]
Free PMC Article

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