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J Clin Med. 2015 Apr 3;4(4):593-613. doi: 10.3390/jcm4040593.

Biological Treatments in Atopic Dermatitis.

Author information

1
Department of Dermatology, Hospital Universitario de La Princesa, Diego de León 62, Madrid 28006, Spain. andreamtg@hotmail.com.
2
Department of Dermatology, Hospital Universitario de La Princesa, Diego de León 62, Madrid 28006, Spain. mar.llamasvelasco@gmail.com.
3
Department of Dermatology, Hospital Universitario de La Princesa, Diego de León 62, Madrid 28006, Spain. aperezplaza@gmail.com.
4
Department of Dermatology, Hospital Universitario de La Princesa, Diego de León 62, Madrid 28006, Spain. guitje1@hotmail.com.
5
Department of Dermatology, Hospital Universitario de La Princesa, Diego de León 62, Madrid 28006, Spain. jsanchezperez@aedv.es.

Abstract

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases that affect both children and adults with a prevalence of 30% and 10%, respectively. Even though most of patients respond satisfactory to topical anti-inflammatory drugs, about 10% require one or more systemic treatments to achieve good control of their illness. The progressive and increasingly detailed knowledge in the immunopathogenesis of AD has allowed research on new therapeutic targets with very promising results in the field of biological therapy. In this article, we will review the different biological treatments with a focus on novel drugs. Their mechanism of action, current status and results from clinical trials and observational studies will be specified.

KEYWORDS:

antibody therapy; atopic dermatitis; atopic eczema; biologics; pathogenesis

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