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Rev Alerg Mex. 2015 Jul-Sep;62(3):211-8.

[Radiographic changes in children with primary immunodeficiency].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Hospital Infantil de México Federico Gómez, Secretaría de Salud, Distrito Federal, México. dr.victorgonzalezu@gmail.com.

Abstract

in English, Spanish

BACKGROUND:

Although we have epidemiological information on primary immunodeficiencies (PID), the available information is meager in Mexico.

OBJECTIVE:

To provide epidemiological information on the delay in the diagnosis of PID and its correlation to chronic lung damage.

MATERIAL AND METHOD:

A retrospective, analytical study was done in patients 0-18 year old age diagnosed with PID for 11 years at the HIMFG (Hospital Infantil de Mexico Federico Gomez). The variables studied were: age at symptom onset, age at diagnosis, time from onset of symptoms to diagnosis, number of previous pneumonias and studies with radiographic chronic lung damage data.

RESULTS:

48 patients were obtained after meeting inclusion criteria; 33 showed lung damage at diagnosis, antibody deficiency being the most affected group. Relating age of onset of symptoms and the time difference of the onset of symptoms to diagnosis showed a strong correlation (p < 0.001, Rho > 0.80). A moderate correlation between the observed time difference vs number of pneumonias (p=0.005, Rho=0.495) and correlation between number of pneumonia and lung damage was highly significant (p <0.001, Rho=0.704).

CONCLUSION:

A strong relationship between the elapsed time from onset of symptoms and the number of pneumonia with lung injury time was found. So, the recurrent pneumonia (> 2) must make suspect the diagnosis of PID, as recommended in the literature.

KEYWORDS:

chronic pulmonary disease; late diagnosis; pneumonia; primary immunodeficiency

PMID:
26239331

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