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J Neurol. 2015 Nov;262(11):2472-7. doi: 10.1007/s00415-015-7866-5. Epub 2015 Aug 5.

Walking improvements with nabiximols in patients with multiple sclerosis.

Author information

1
Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy. gccoghe@gmail.com.
2
Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, Cagliari, Italy.
3
Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy.
4
ASL 8 Cagliari, Multiple Sclerosis Centre, Cagliari, Italy.

Abstract

Recently, nabiximols was approved as a treatment in MS spasticity. Data leading to approval and clinical use of nabiximols, although widely recognised, are based on subjective scales. Movement analysis procedures would obtain more detailed data about the impact on mobility. The aim of the study was to quantitatively assess the functional modification of gait patterns induced by nabiximols in MS. We evaluated three-dimensional gait analysis (spatial-temporal and kinematic) variation by means of one-way ANOVA. Twenty patients were enrolled-9 male and 11 female-with mean EDSS of 5.3 (SD ± 0.81) and mean reduction of numerical rating scale during nabiximols treatment of 1.88. The spatial-temporal parameters of gait revealed an increased speed (+15 %, p < 0.001), cadence (+6 %, p < 0.001) and stride length (+10 %, p < 0.001) after treatment. Regarding the kinematics data, the Gait Profile Score after treatment was reduced by 10 % (p < 0.001): Significant changes involved the pelvic area, hip rotation and knee flexion-extension. We found that nabiximols is able to improve the speed, cadence and stride length. Furthermore, the dynamics of the proximal segment of the legs and the knee movement results after treatment are closer to the physiologic values.

KEYWORDS:

Ambulation; Gait analysis; Multiple sclerosis; Nabiximols; Sativex; Spasticity

PMID:
26239223
DOI:
10.1007/s00415-015-7866-5
[Indexed for MEDLINE]

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