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J Lipid Res. 2015 Oct;56(10):1985-92. doi: 10.1194/jlr.P058578. Epub 2015 Aug 3.

Omental adipocyte hypertrophy relates to coenzyme Q10 redox state and lipid peroxidation in obese women.

Author information

1
Endocrinology and Nephrology Axis, Centre Hospitalier Universitaire de Québec, Québec, Canada Department of Medicine, Division of Endocrinology, Université de Sherbrooke, Québec, Canada.
2
CNRS 5273, UMR STROMALab, Toulouse, France Université de Toulouse, UPS, Toulouse, France INSERM U1031, Toulouse, France EFS Pyrénées-Méditerranée, Toulouse, France.
3
Department of Medicine, Division of Endocrinology, Université de Sherbrooke, Québec, Canada.
4
Endocrinology and Nephrology Axis, Centre Hospitalier Universitaire de Québec, Québec, Canada.

Abstract

Occurrence of oxidative stress in white adipose tissues contributes to its dysfunction and the development of obesity-related metabolic complications. Coenzyme Q10 (CoQ10) is the single lipophilic antioxidant synthesized in humans and is essential for electron transport during mitochondrial respiration. To understand the role of CoQ10 in adipose tissue physiology and dysfunction, the abundance of the oxidized and reduced (CoQ10red) isoforms of the CoQ10 were quantified in subcutaneous and omental adipose tissues of women covering the full range of BMI (from 21.5 to 53.2 kg/m(2)). Lean women displayed regional variations of CoQ10 redox state between the omental and subcutaneous depot, despite similar total content. Obese women had reduced CoQ10red concentrations in the omental depot, leading to increased CoQ10 redox state and higher levels of lipid hydroperoxide. Women with low omental CoQ10 content had greater visceral and subcutaneous adiposity, increased omental adipocyte diameter, and higher circulating interleukin-6 and C-reactive protein levels and were more insulin resistant. The associations between abdominal obesity-related cardiometabolic risk factors and CoQ10 content in the omental depot were abolished after adjustment for omental adipocyte diameter. This study shows that hypertrophic remodeling of visceral fat closely relates to depletion of CoQ10, lipid peroxidation, and inflammation.

KEYWORDS:

adipocytes; adipose tissue; antioxidant; body fat distribution; cardiometabolic risk factors; mitochondria; obesity; ubiquinol; ubiquinone

PMID:
26239051
PMCID:
PMC4583084
DOI:
10.1194/jlr.P058578
[Indexed for MEDLINE]
Free PMC Article

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