Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Sylvia T Gunawan; Kristian Kempe; Thomas Bonnard; Jiwei Cui; Karen Alt; Lok S Law; Xiaowei Wang; Erik Westein; Georgina K Such; Karlheinz Peter; Christoph E Hagemeyer; Frank Caruso

doi:10.1002/adma.201502243

Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Adv Mater. 2015 Sep 16;27(35):5153-7. doi: 10.1002/adma.201502243. Epub 2015 Aug 3.

Authors

Affiliations

¹ ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
² Department of Chemistry, University of Warwick, CV 4 7AL, Coventry, UK.
³ Vascular Biotechnology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.
⁴ Atherothrombosis and Vascular Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.
⁵ Department of Chemistry, The University of Melbourne, Parkville, Victoria, 3010, Australia.

PMID: 26239035
DOI: 10.1002/adma.201502243

Abstract

Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.

Keywords: antibodies; drug delivery; plasminogen activators; polymer carriers; thrombosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Blood Platelets / drug effects*
Blood Platelets / physiology*
Capsules
Drug Carriers / chemistry*
Humans
Oligopeptides / chemistry
Oxazoles / chemistry*
Platelet Activation / drug effects*
Thrombin / metabolism*
Thrombosis / physiopathology
Urokinase-Type Plasminogen Activator / chemistry
Urokinase-Type Plasminogen Activator / metabolism
Urokinase-Type Plasminogen Activator / pharmacology

Substances

Capsules
Drug Carriers
Oligopeptides
Oxazoles
poly(2-oxazoline)
arginyl-glycyl-aspartic acid
Thrombin
Urokinase-Type Plasminogen Activator