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Cold Spring Harb Perspect Biol. 2015 Aug 3;7(8):a019141. doi: 10.1101/cshperspect.a019141.

The opposing actions of target of rapamycin and AMP-activated protein kinase in cell growth control.

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1
Biozentrum, University of Basel, CH4056 Basel, Switzerland.

Abstract

Cell growth is a highly regulated, plastic process. Its control involves balancing positive regulation of anabolic processes with negative regulation of catabolic processes. Although target of rapamycin (TOR) is a major promoter of growth in response to nutrients and growth factors, AMP-activated protein kinase (AMPK) suppresses anabolic processes in response to energy stress. Both TOR and AMPK are conserved throughout eukaryotic evolution. Here, we review the fundamentally important roles of these two kinases in the regulation of cell growth with particular emphasis on their mutually antagonistic signaling.

PMID:
26238356
PMCID:
PMC4526743
DOI:
10.1101/cshperspect.a019141
[Indexed for MEDLINE]
Free PMC Article
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