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Sleep. 2015 Dec 1;38(12):1905-12. doi: 10.5665/sleep.5238.

Contribution of Inflammation, Oxidative Stress, and Antioxidants to the Relationship between Sleep Duration and Cardiometabolic Health.

Author information

1
School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.

Abstract

OBJECTIVES:

To explore the interrelationship and mediating effect of factors that are beneficial (i.e., antioxidants) and harmful (i.e., inflammation and oxidative stress) to the relationship between sleep and cardiometabolic health.

DESIGN:

Cross-sectional data from the 2005-2006 National Health and Nutrition Examination Survey.

SETTING:

Nationally representative population sample from the US.

PARTICIPANTS:

Age ≥ 20 y with sleep data; final analytical sample of n = 2,079.

INTERVENTIONS:

N/A.

MEASUREMENTS AND RESULTS:

Metabolic syndrome was classified according to the Joint Interim Statement, and sleep duration was categorized as very short, short, adequate, and long sleepers (≤ 4, 5-6, 7-8, and ≥ 9 h per night, respectively). The indirect mediation effect was quantified as large (≥ 0.25), moderate (≥ 0.09), modest (≥ 0.01), and weak (< 0.01). In general, inflammation was above the current clinical reference range across all sleep duration categories, whereas oxidative stress was elevated among short and very short sleepers. Select sleep duration- cardiometabolic health relationships were mediated by C-reactive protein (CRP), γ-glutamyl transferase (GGT), carotenoids, uric acid, and vitamins C and D, and were moderated by sex. Specifically, moderate-to-large indirect mediation by GGT, carotenoids, uric acid, and vitamin D were found for sleep duration-waist circumference and -systolic blood pressure relationships, whereas vitamin C was a moderate mediator of the sleep duration-diastolic blood pressure relationship.

CONCLUSIONS:

Several factors related to inflammation, oxidative stress, and antioxidant status were found to lie on the casual pathway of the sleep duration-cardiometabolic health relationship. Further longitudinal studies are needed to confirm our results.

KEYWORDS:

antioxidants; cardiometabolic health; indirect mediation effect; inflammation and oxidative stress; sleep duration

PMID:
26237775
PMCID:
PMC4667380
DOI:
10.5665/sleep.5238
[Indexed for MEDLINE]
Free PMC Article

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