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J Clin Biochem Nutr. 2015 Jul;57(1):44-9. doi: 10.3164/jcbn.15-21. Epub 2015 Jun 4.

The effects of moderate exercise on secretory IgA production in mice depends on dietary carbohydrate intake.

Author information

1
Division of Cell Biology, Graduate School of Sports and Health Science, Daito Bunka University, 560 Iwadono, Higashi-Matsuyama, Saitama 355-8501, Japan.
2
Division of Nutrition, Department of Health Science, Faculty of Sports and Health Sciences, Daito Bunka University, 560 Iwadono, Higashi-Matsuyama, Saitama 355-8501, Japan.
3
Laboratory of Food and Regulation Biology, Department of Bioscience, School of Agriculture, Tokai University, Kawayou, Minamiaso, Aso-gun, Kumamoto 869-1404, Japan.

Abstract

Secretory immunoglobulin A (sIgA) is produced from intestinal mucosa and is essential in preventing infection. We analyzed the influence of moderate exercise on intestinal sIgA production and antioxidative function under different carbohydrate nutritional conditions. Thirty-six mice were fed an experimental diet for 10 weeks-a high-carbohydrate (HC) diet, a low-carbohydrate (LC) diet, or a control (C) diet. After 1 week on the experimental diets, mice were divided into sedentary and exercise groups (n = 6/group), where the exercise consisted of treadmill running for 30 min/day at 11 m/min for 6 days/week in 9 consecutive weeks. Intestinal sIgA levels in the exercise groups fed C or LC diets were significantly lower compared with the parallel sedentary groups, or exercise-group mice fed HC diet. Expression of the polymeric immunoglobulin receptor (pIgR) in the small intestine was significantly higher in the exercise group fed a HC diet. Superoxide dismutase activity in the small intestine was higher in the exercise group than in the sedentary group, with no effects resulting from intake carbohydrate levels. Our results indicated that moderate exercise reduced the levels of intestinal sIgA depending on decreasing of carbohydrate intake, which is connected with the expression of pIgR.

KEYWORDS:

SOD; carbohydrate intake; moderate exercise; pIgR; sIgA

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