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Acta Otolaryngol. 2015;135(11):1178-84. Epub 2015 Aug 1.

Effects of local application of methylprednisolone delivered by the C/GP-hydrogel on the recovery of facial nerves.

Author information

1
a 1 Department of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Shandong Institute of Otolaryngology , Jinan, PR China.
2
b 2 Department of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University , Jinan, PR China.
3
c 3 Department of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, People's Hospital of Rizhao , Rizhao, PR China.
4
d 4 Co-innovation Center of Neuroregeneration, Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing , PR China.

Abstract

CONCLUSIONS:

Local administration of MP delivered by the C/GP-MP-hydrogel can improve the recovery of facial nerve following crush injury. The findings suggested that locally injected MP delivered by C/GP-hydrogel might be a promising treatment for facial nerve damage.

OBJECTIVES:

In this study, the aim is to assess the effectiveness of locally administrating methylprednisolone(MP) loaded by chitosan-β-glycerophosphate hydrogel (C/GP-hydrogel) on the regeneration of facial nerve crush injury.

METHODS:

After the crush of left facial nerves, Wistar rats were randomly divided into four different groups. Then, four different therapies were used to treat the damaged facial nerves. At the 1(st), 2(nd), 3(rd), and 4(th) week after injury, the functional recovery of facial nerves and the morphological changes of facial nerves were assessed. The expression of growth associated protein-43 (GAP-43) protein in the facial nucleus were also evaluated.

RESULTS:

Locally injected MP delivered by C/GP-hydrogel effectively accelerated the facial functional recovery. In addition, the regenerated facial nerves in the C/GP-MP group were more mature than those in the other groups. The expression of GAP-43 protein was also improved by the MP, especially in the C/GP-MP group.

KEYWORDS:

C/GP-hydrogel; Facial paralysis; chitosan; methylprednisolone; nerve regeneration

PMID:
26235110
[Indexed for MEDLINE]

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