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Neurobiol Aging. 2015 Oct;36(10):2812-20. doi: 10.1016/j.neurobiolaging.2015.07.002. Epub 2015 Jul 9.

PCC characteristics at rest in 10-year memory decliners.

Author information

1
Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), University of Bordeaux, UMR 5287, Talence, France; Centre National de la Recherche Scientifique (CNRS), INCIA, UMR 5287, Talence, France; Ecole Pratique des Hautes Etudes (EPHE), Bordeaux, France. Electronic address: charlotte.bernard1@yahoo.fr.
2
Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), University of Bordeaux, UMR 5287, Talence, France; Centre National de la Recherche Scientifique (CNRS), INCIA, UMR 5287, Talence, France.
3
Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; University of Bordeaux, Bordeaux, France; INSERM, Clinical Investigation Center-Clinical Epidemiology 7, Bordeaux, France.
4
Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), University of Bordeaux, UMR 5287, Talence, France; Centre National de la Recherche Scientifique (CNRS), INCIA, UMR 5287, Talence, France; Ecole Pratique des Hautes Etudes (EPHE), Bordeaux, France.
5
Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; University of Bordeaux, Bordeaux, France.
6
Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; University of Bordeaux, Bordeaux, France; Memory Consultation, University Hospital, Centre Mémoire de Ressources et de Recherche (CMRR), Bordeaux, France.

Abstract

The present research sought to characterize the intrinsic functional networks associated with a 10-year episodic memory decline in elderly using data from a longitudinal population-based cohort (Bordeaux-3City). Complementary measures of whole-brain resting-state functional magnetic resonance imaging investigations were combined to compare functional architecture of brain networks both at connectional and topological levels in 22 decliners to 22 nondecliners; episodic memory decline being assessed through a multiple time point Free and Cued Selective Reminding Test. The decliners presented differences in functional architecture centered on the posterior cingulate cortex, characterized by a significant decrease of connectivity intensity, a significant increased centrality. In accordance, a decrease of the functional connectivity inside the default mode network was observed in the decliners. Our results highlight the central role of the posterior cingulate cortex in a slow but reliable memory decline in elderly. Because functional alterations of this region are currently described in Alzheimer's disease, this functional signature could constitute a risk for Alzheimer's disease.

KEYWORDS:

Aging; Graph theory; Memory decline; NBS; PCC; Resting-state fMRI

[Indexed for MEDLINE]

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