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J Pediatr. 2015 Dec;167(6):1259-63.e1. doi: 10.1016/j.jpeds.2015.07.006. Epub 2015 Jul 29.

Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes.

Author information

1
Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Developmental Pediatrics, SPZ, Kantonsspital Winterthur, Winterthur, Switzerland; Children's Research Center, University Children's Hospital, Zurich, Switzerland.
2
Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
3
Department of Neonatology, University Hospital Zurich, Zurich, Switzerland.
4
Congenital Cardiovascular Surgery, University Children's Hospital Zurich, Zurich, Switzerland.
5
Children's Research Center, University Children's Hospital, Zurich, Switzerland; Department of Neonatology and Intensive Care, University Children's Hospital Zurich, Zurich, Switzerland.
6
Diagnostic Imaging, University Children's Hospital, Zurich, Switzerland.
7
Children's Research Center, University Children's Hospital, Zurich, Switzerland; Cardiology, University Children's Hospital, Zurich, Switzerland.
8
Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Children's Research Center, University Children's Hospital, Zurich, Switzerland.

Abstract

OBJECTIVES:

To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth.

STUDY DESIGN:

Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions.

RESULTS:

Preoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P < .001).

CONCLUSIONS:

Infants with CHD undergoing bypass surgery have smaller brain volumes prior to surgery without a specific regional predilection. This suggests a fetal origin of reduced brain growth.

PMID:
26233604
DOI:
10.1016/j.jpeds.2015.07.006
[Indexed for MEDLINE]

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