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Environ Toxicol Pharmacol. 2015 Sep;40(2):369-74. doi: 10.1016/j.etap.2015.07.001. Epub 2015 Jul 4.

Developmental exposure to paracetamol causes biochemical alterations in medulla oblongata.

Author information

1
Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Banacha 1B, 02-097 Warsaw, Poland.
2
Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Banacha 1B, 02-097 Warsaw, Poland. Electronic address: etyszkiewicz@wum.edu.pl.

Abstract

The effect and safety of prenatal and early life administration of paracetamol - routinely used over-the-counter antipyretic and analgesic medication on monoamines content and balance of amino acids in the medulla oblongata is still unknown. In this study we have determined the level of neurotransmitters in this structure in two-month old Wistar male rats exposed to paracetamol in the dose of 5 (P5, n=10) or 15mg/kg b.w. (P15, n=10) during prenatal period, lactation and till the end of the second month of life. Control group received drinking water (Con, n=10). Monoamines, their metabolites and amino acids concentration in medulla oblongata of rats were determined using high performance liquid chromatography (HPLC) in 60 postnatal day (PND60). This experiment shows that prenatal and early life paracetamol exposure modulates neurotransmission associated with serotonergic, noradrenergic and dopaminergic system in medulla oblongata. Reduction of alanine and taurine levels has also been established.

KEYWORDS:

Acetaminophen; Amino acids; CNS; Medulla oblongata; Neurotransmission; Paracetamol

PMID:
26233562
DOI:
10.1016/j.etap.2015.07.001
[Indexed for MEDLINE]

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