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Environ Toxicol Pharmacol. 2015 Sep;40(2):349-51. doi: 10.1016/j.etap.2015.07.008. Epub 2015 Jul 14.

Influence of dioxin on the daily variation of insulin sensitivity in mice.

Author information

1
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan.
2
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan. Electronic address: akiofuji@jichi.ac.jp.

Abstract

To evaluate an influence of dioxin on a daily variation of insulin sensitivity, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100ng/kg) was given for 3 weeks in mice. Insulin tolerance test and oral glucose tolerance test were performed. TCDD decreased insulin sensitivity at an active period, but not at a rest period. TCDD elevated plasma TNF-α, and the value was significantly higher during an active period than during a rest period. These data suggest that TCDD blunts insulin sensitivity, mainly during an active period. Higher elevation in plasma TNF-α during an active period might be involved in this phenomenon.

KEYWORDS:

Chronotoxicology; Dioxin; Insulin sensitivity; TNF-α

PMID:
26233560
DOI:
10.1016/j.etap.2015.07.008
[Indexed for MEDLINE]

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