Format

Send to

Choose Destination
See comment in PubMed Commons below
J Rheumatol. 2015 Sep;42(9):1556-62. doi: 10.3899/jrheum.141629. Epub 2015 Aug 1.

Does Rheumatoid Cachexia Predispose Patients with Rheumatoid Arthritis to Osteoporosis and Vertebral Fractures?

Author information

  • 1From the Rheumatology Department, Military Hospital Mohammed V, Rabat, Morocco.A. El Maghraoui, MD, Professor of Rheumatology; S. Sadni, MD, Fellow of Rheumatology; A. Rezqi, MD, Rheumatologist; A. Bezza, MD, Professor of Rheumatology; L. Achemlal, MD, Professor of Rheumatology; A. Mounach, MD, Rheumatologist, Rheumatology Department, Military Hospital Mohammed V. aelmaghraoui@gmail.com.
  • 2From the Rheumatology Department, Military Hospital Mohammed V, Rabat, Morocco.A. El Maghraoui, MD, Professor of Rheumatology; S. Sadni, MD, Fellow of Rheumatology; A. Rezqi, MD, Rheumatologist; A. Bezza, MD, Professor of Rheumatology; L. Achemlal, MD, Professor of Rheumatology; A. Mounach, MD, Rheumatologist, Rheumatology Department, Military Hospital Mohammed V.

Abstract

OBJECTIVE:

To assess the prevalence and risk factors of rheumatoid cachexia (RC) and evaluate its relationship with osteoporosis and vertebral fractures (VF) in patients with rheumatoid arthritis (RA).

METHODS:

We enrolled into a cross-sectional study 178 consecutive patients with RA (82.6% women) with a mean age of 54.1 ± 11.5 years (25-82) and who fulfilled the American College of Rheumatology criteria for the classification of RA. Body composition, lateral VF assessment images, and scans of the lumbar spine and proximal femur were obtained using dual-energy x-ray absorptiometry. RC was defined by a fat-free mass index below the 10th percentile and a fat mass index above the 25th percentile compared with a reference population. VF were defined using Genant semiquantitative approach.

RESULTS:

RC was observed in 96 patients (53.9%) and osteoporosis in 52 patients (29.2%). Comparison between women with and without RC showed that women with RC had a longer disease duration, higher disease activity variables, higher steroid cumulative dose, and higher proportion of patients with erosive arthritis. Women with RC had lower total hip bone mineral density (BMD) and T score than women without RC, while comparison in men found only body mass index to be significantly lower in men with RC. Regression logistic analysis showed an independent and significant association between RC and age and disease activity in women.

CONCLUSION:

Our study showed that half of the patients with RA may have RC, a condition that was significantly associated with disease activity and low hip BMD, but not with VF.

KEYWORDS:

ADIPOSE TISSUE; DUAL-ENERGY X-RAY ABSORPTIOMETRY; OSTEOPOROSIS; RHEUMATOID ARTHRITIS; VERTEBRAL FRACTURES

PMID:
26233497
DOI:
10.3899/jrheum.141629
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center