Format

Send to

Choose Destination
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Oct;120(4):483-96. doi: 10.1016/j.oooo.2015.06.005. Epub 2015 Jun 15.

Clear cell odontogenic carcinoma: report of 7 new cases and systematic review of the current knowledge.

Author information

1
Department of Oral and Maxillofacial Pathology, Federal University of Uberlândia, Uberlândia (MG), Brazil. Electronic address: loyolaam@yahoo.com.br.
2
Department of Morphology, Biomedical Science Institute, Federal University of Uberlândia, Uberlândia (MG), Brazil.
3
Department of Oral and Maxillofacial Pathology, Federal University of Uberlândia, Uberlândia (MG), Brazil.
4
Division of Pathology, Brazilian National Institute of Cancer, Rio de Janeiro (RJ), Brazil.
5
Division of Head and Neck Surgery, Brazilian National Institute of Cancer, Rio de Janeiro (RJ), Brazil.
6
Department of Pathology, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil.
7
Department of Oral Surgery and Pathology, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil.

Abstract

OBJECTIVE:

The goal of this study is to describe 7 cases of clear cell odontogenic carcinoma among a Brazilian population and compare these data with a systematic review of the English-language literature.

STUDY DESIGN:

Descriptive statististics were used to compare the clinicopathologic data gathered retrospectively with those compiled from a review. Tumor sections were immunostained for Ki-67, p16, p53, and cytokeratins (CKs) 7, 8, 14, 18, and 19. Log-rank tests were performed for survival analysis.

RESULTS:

Most cases occurred in the posterior mandible (5/7, 71.4%), and recurrence was diagnosed in all treated patients. Metastatic disease occurred in 2 patients (28.6%). Tumors were focally positive for CKs 7, 8, 14, and 18 and diffusely positive for CK19, p53, and p16. The mean number of Ki-67-positive cells was 35.2 cells/high-power field. Our systematic review provided evidence that tumor size (P = .046), histologic pattern (P = .034), regional metastasis (P = .001), distant metastasis (P = .001), and local recurrence (P = .05) were of significant prognostic value.

CONCLUSIONS:

This study has contributed to improved characterization of clear cell odontogenic carcinoma, which is an aggressive odontogenic malignant neoplasm diagnosed mainly in the posterior mandible of middle-aged women and typically at an advanced stage. Radical surgical procedures remain the gold standard treatment.

PMID:
26232924
DOI:
10.1016/j.oooo.2015.06.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center