Format

Send to

Choose Destination
Reprod Toxicol. 2015 Dec;58:33-44. doi: 10.1016/j.reprotox.2015.07.075. Epub 2015 Jul 29.

NIEHS/FDA CLARITY-BPA research program update.

Author information

1
National Institute of Environmental Health Sciences/National Institutes of Health, Division of Extramural Research and Training, Research Triangle Park, NC 27709, United States. Electronic address: heindelj@niehs.nih.gov.
2
National Institute of Environmental Health Sciences/National Institutes of Health, Division of the National Toxicology Program, Research Triangle Park, NC 27709, United States.
3
Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States.
4
Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States.
5
Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States.
6
Department of Comparative Biosciences, University of Illinois, Urbana, IL 61802, United States.
7
Biology Department, University of Massachusetts, Amherst, MA 01003, United States.
8
Team Vistronix, NTP Computer and User Support, National Institute of Environmental Health Sciences/National Institutes of Health, Division of the National Toxicology Program, Research Triangle Park, NC 27709, United States.
9
National Institute of Environmental Health Sciences/National Institutes of Health, Division of Extramural Research and Training, Research Triangle Park, NC 27709, United States.

Abstract

Bisphenol A (BPA) is a chemical used in the production of numerous consumer products resulting in potential daily human exposure to this chemical. The FDA previously evaluated the body of BPA toxicology data and determined that BPA is safe at current exposure levels. Although consistent with the assessment of some other regulatory agencies around the world, this determination of BPA safety continues to be debated in scientific and popular publications, resulting in conflicting messages to the public. Thus, the National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), and U.S. Food and Drug Administration (FDA) developed a consortium-based research program to link more effectively a variety of hypothesis-based research investigations and guideline-compliant safety testing with BPA. This collaboration is known as the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA). This paper provides a detailed description of the conduct of the study and a midterm update on progress of the CLARITY-BPA research program.

KEYWORDS:

Bisphenol A; CLARITY-BPA; Consortium; Endocrine disruptors; FDA; NIEHS; NTP

PMID:
26232693
PMCID:
PMC5545120
DOI:
10.1016/j.reprotox.2015.07.075
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center