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Am J Obstet Gynecol. 2015 Dec;213(6):839.e1-8. doi: 10.1016/j.ajog.2015.07.034. Epub 2015 Jul 29.

Fetal programming and systemic sclerosis.

Author information

1
Department of Fetal-Neonatal Medicine, Meyer Children's Hospital, University of Florence, Florence, Italy. Electronic address: gianpaolo.donzelli@unifi.it.
2
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
3
Department of Fetal-Neonatal Medicine, Meyer Children's Hospital, University of Florence, Florence, Italy.
4
Department of Health Sciences, University of Florence, Florence, Italy.
5
Department of Rheumatology, University and IRCCS Foundation, Policlinico San Matteo, Pavia, Italy.
6
Department of Internal Medicine and Clinical Specialties, Rheumatology Unit, "La Sapienza" University, Rome, Italy.
7
Institute of General Clinical Medicine, Hematology, and Clinical Immunology, University of Ancona, Ancona, Italy.
8
Research, Innovation, and International Relations Office, Meyer Children's Hospital, University of Florence, Florence, Italy.

Abstract

OBJECTIVE:

This study investigated whether birthweight is linked to an increased risk of the development of systemic sclerosis.

STUDY DESIGN:

This was a multicenter case-control study with perinatal data that were obtained from 332 cases with systemic sclerosis and 243 control subjects. Birthweight was treated as a dichotomous variable (<2500 g vs ≥2500 g); low birthweight was defined as a weight <2500 g; small for gestational age was defined as birthweight <10th percentile for gestational age adjusted for sex. The relationship between systemic sclerosis and both low birthweight and small for gestational age was expressed with the crude (univariate analysis) and adjusted (multivariate analysis) odds ratio (OR).

RESULTS:

Significantly increased ORs were observed in the univariate analysis for low birthweight (OR, 2.59; 95% confidence interval [CI], 1.39-5.05) and small for gestational age (OR, 2.60; 95% CI, 1.34-5.32) subjects. Similarly increased risks were confirmed for both conditions in the multivariate analysis (OR, 3.93; 95% CI, 1.92-8.07; and OR, 2.58; 95% CI, 1.28-5.19), respectively.

CONCLUSION:

Low birthweight and small for gestational age at birth are risk factors for the adult onset of systemic sclerosis.

KEYWORDS:

autoimmune disease; birthweight; epigenetics; fetal programming; scleroderma

PMID:
26232509
DOI:
10.1016/j.ajog.2015.07.034
[Indexed for MEDLINE]

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