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Cell. 2015 Jul 30;162(3):488-92. doi: 10.1016/j.cell.2015.07.005.

Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control.

Author information

1
Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: diamond@wusm.wustl.edu.
2
Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: piersontc@mail.nih.gov.

Abstract

Dengue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans each year. Here, we review recent advances in our understanding of the biology of DENV and describe knowledge gaps that have impacted the development of effective vaccines and therapeutics.

PMID:
26232221
PMCID:
PMC4522276
DOI:
10.1016/j.cell.2015.07.005
[Indexed for MEDLINE]
Free PMC Article

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