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Curr Opin Genet Dev. 2015 Aug;33:1-9. doi: 10.1016/j.gde.2015.06.004. Epub 2015 Jul 29.

The short and long telomere syndromes: paired paradigms for molecular medicine.

Author information

1
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
2
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States. Electronic address: marmani1@jhmi.edu.

Abstract

Recent advances have defined a role for abnormally short telomeres in a broad spectrum of genetic disorders. They include rare conditions such as dyskeratosis congenita as well pulmonary fibrosis and emphysema. Now, there is new evidence that some familial cancers, such as melanoma, are caused by mutations that lengthen telomeres. Here, we examine the significance of these short and long telomere length extremes for understanding the molecular basis of age-related disease and cancer.

PMID:
26232116
PMCID:
PMC4741306
DOI:
10.1016/j.gde.2015.06.004
[Indexed for MEDLINE]
Free PMC Article
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