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Am J Hypertens. 2016 Apr;29(4):501-8. doi: 10.1093/ajh/hpv128. Epub 2015 Jul 31.

Association of Endothelial and Mild Renal Dysfunction With the Severity of Left Ventricular Hypertrophy in Hypertensive Patients.

Author information

1
Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China;
2
Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China; Key Laboratory of Molecular Biology in Jiangxi Province, Nanchang City, Jiangxi Province, China. yf_dong66@126.com.

Abstract

BACKGROUND:

The association between impaired renal function and increase left ventricular mass was shown to be related to increase in arterial stiffness, which indicates that vascular homeostasis and remodeling may impact the left ventricular hypertrophy (LVH) in patients with renal dysfunction.

METHODS:

We measured the peripheral arterial reactive hyperemia index (RHI) and estimated glomerular filtration rate (eGFR) in 317 hypertensive patients comprising 115 normal RHI (RHI > 1.67) and normal eGFR (eGFR ≥ 90ml/min per 1.73 m(2)), 136 low RHI (RHI ≤ 1.67), 27 low eGFR (60 ≤ eGFR < 90ml/min per 1.73 m(2)) and 39 low RHI combined with low eGFR.

RESULTS:

Multivariate logistic regression analysis identified lg RHI (odds ratio (OR): 0.001, 95% confidence interval (CI): 10(-6) to 0.426, P = 0.024) and lg eGFR (OR: 0.009, 95% CI: 10(-4) to 0.414, P = 0.016) as independent factors correlated with LVH respectively in hypertensive patients. Compared with normal RHI and eGFR patients, the extent of LVH in patients with either low RHI (OR: 1.224 95% CI: 0.451 to 3.327, P = 0.691) or low eGFR (OR: 0.593 95% CI: 0.070 to 5.037, P = 0.632) did not significantly increase, while it increased significantly in patients with low RHI combined with low eGFR (OR: 4.629 95% CI: 1.592 to 13.458, P = 0.005).

CONCLUSIONS:

The concurrence of endothelial and mild renal dysfunction was significantly associated with the severity of LVH in hypertensive patients.

KEYWORDS:

blood pressure; endothelial dysfunction; hypertension; left ventricular hypertrophy; renal dysfunction.

PMID:
26232035
PMCID:
PMC4886486
DOI:
10.1093/ajh/hpv128
[Indexed for MEDLINE]
Free PMC Article

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