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FEBS Lett. 2015 Sep 14;589(19 Pt A):2464-76. doi: 10.1016/j.febslet.2015.07.024. Epub 2015 Jul 29.

Order and disorder in intermediate filament proteins.

Author information

1
School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel.
2
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
3
School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel. Electronic address: roy@post.tau.ac.il.

Abstract

Intermediate filaments (IFs), important components of the cytoskeleton, provide a versatile, tunable network of self-assembled proteins. IF proteins contain three distinct domains: an α-helical structured rod domain, flanked by intrinsically disordered head and tail domains. Recent studies demonstrated the functional importance of the disordered domains, which differ in length and amino-acid sequence among the 70 different human IF genes. Here, we investigate the biophysical properties of the disordered domains, and review recent findings on the interactions between them. Our analysis highlights key components governing IF functional roles in the cytoskeleton, where the intrinsically disordered domains dictate protein-protein interactions, supramolecular assembly, and macro-scale order.

KEYWORDS:

Cytoskeleton; Intermediate filament; Intrinsically disordered protein; Polymer brush; Self-assembly

PMID:
26231765
DOI:
10.1016/j.febslet.2015.07.024
[Indexed for MEDLINE]
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