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Curr Opin Chem Biol. 2015 Dec;29:18-25. doi: 10.1016/j.cbpa.2015.06.032. Epub 2015 Jul 29.

Biocatalysts for biomass deconstruction from environmental genomics.

Author information

1
Genome Science and Technology Program, University of British Columbia, Vancouver, Canada.
2
MetaMixis Biologics Inc., Vancouver, BC, Canada.
3
Genome Science and Technology Program, University of British Columbia, Vancouver, Canada; MetaMixis Biologics Inc., Vancouver, BC, Canada; Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada. Electronic address: shallam@mail.ubc.ca.

Abstract

Plant biomass offers a sustainable alternative to the energy and materials produced from fossil fuels. The industrial scale production or biorefining of fermentable sugars and aromatics from plant biomass is currently limited by the lack of cost effective and efficient biocatalysts. One potential solution to this problem is the discovery of biomass deconstructing biocatalysts from uncultivated microbial communities. Here we review recent progress in recovering such biological devices from environmental genomes and consider how this information can be used to build better biorefining ecosystems.

PMID:
26231123
DOI:
10.1016/j.cbpa.2015.06.032
[Indexed for MEDLINE]

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