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Nat Prod Res. 2016;30(5):565-9. doi: 10.1080/14786419.2015.1033624. Epub 2015 Jul 31.

A new sesquiterpenoid quinone with cytotoxicity from Abelmoschus sagittifolius.

Author information

1
a Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine) , Chinese Academy of Medical Sciences & Peking Union Medical College , Wanning 571533 , P.R. China.
2
b School of Pharmaceutical Science , Hainan Medical University , No.3 Xueyuan Road, Longhua District, Haikou 571101 , P.R. China.
3
c Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences & Peking Union Medical College , No. 151, Malianwa North Road, Haidian District, Beijing 100193 , P.R. China.

Abstract

A new sesquiterpenoid quinone, Acyl hibiscone B (1), together with five known compounds, (R)-lasiodiplodin (2), (R)-de-O-methyllasiodiplodin, (3) dibutyl phthalate (4), (R)-9-phenylnonan-2-ol (5) and hibiscone B (6), was obtained from the stem tuber of Abelmoschus sagittifolius. The structure of compound 1 was elucidated by analysing its (1)H and (13)C NMR, (1)H-(1)H COSY, HSQC, HMBC, NOESY and HR-ESI-MS values. Compound 1 showed significant cytotoxicity against Hela and HepG-2 human cancer cell lines.

KEYWORDS:

Abelmoschus sagittifolius; cytotoxicity; sesquiterpenoid

PMID:
26230217
DOI:
10.1080/14786419.2015.1033624
[Indexed for MEDLINE]

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