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Kidney Int. 2015 Aug;88(2):213-5. doi: 10.1038/ki.2015.89.

Inflammation and hypoxia in the kidney: friends or foes?

Author information

1
1] Division of Nephrology and Hypertension, Departments of Medicine, Cancer Biology, and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA [2] Medical and Research Services, Department of Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.

Abstract

Hypoxic injury is commonly associated with inflammatory-cell infiltration, and inflammation frequently leads to the activation of cellular hypoxia response pathways. The molecular mechanisms underlying this cross-talk during kidney injury are incompletely understood. Yamaguchi and colleagues identify CCAAT/enhancer-binding protein δ as a cytokine- and hypoxia-regulated transcription factor that fine-tunes hypoxia-inducible factor-1 signaling in renal epithelial cells and thus provide a novel molecular link between hypoxia and inflammation in kidney injury.

PMID:
26230196
PMCID:
PMC4534718
DOI:
10.1038/ki.2015.89
[Indexed for MEDLINE]
Free PMC Article

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