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Mov Disord. 2015 Sep;30(10):1404-7. doi: 10.1002/mds.26311. Epub 2015 Jul 30.

Appendectomy may delay Parkinson's disease Onset.

Author information

1
Serviço de Neurologia, Centro Hospitalar do Porto, Porto, Portugal.
2
Unidade Multidisciplinar de Investigação Biomedica, Instituto Ciências Biomedicas Abel Salazar, Universidade do Porto, Porto, Portugal.
3
CINTESIS, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
4
Screening and Test Evaluation Program, Sydney School of Public Health, University of Sydney, Sydney, Australia.
5
Serviço de Neuropatologia, Centro Hospitalar do Porto, Porto, Portugal.

Abstract

BACKGROUND:

Alpha-synuclein (α-Syn) is particularly abundant in the vermiform appendix, which makes this structure an anatomical candidate for the initiation of Parkinson's disease (PD) pathology. We hypothesized that history of appendectomy might affect PD clinical onset.

METHODS:

A total of 295 PD patients enrolled in a comprehensive observational study were asked about past history of appendectomy. Cox's regression, with a time-dependent covariate, explored the effects of appendectomy on age at PD onset.

RESULTS:

Thirty-four patients (11.5%) had appendectomy before PD onset. There was no significant effect of appendectomy on age at PD onset for the entire cohort (P = 0.153). However, among patients with late onset (≥55 years), we found evidence that those with past appendectomy had more years of life without PD symptoms than patients without appendectomy (P = 0.040). No association was found for the young-onset group (P = 0.663).

CONCLUSIONS:

An apparent relationship was observed between appendectomy and PD onset in the late PD cohort.

KEYWORDS:

Parkinson's disease; appendectomy; disease onset; vermiform appendix; α-synuclein

PMID:
26228745
DOI:
10.1002/mds.26311
[Indexed for MEDLINE]

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