Format

Send to

Choose Destination
World J Surg Oncol. 2015 Jul 31;13:231. doi: 10.1186/s12957-015-0648-9.

Phytoestrogens and risk of prostate cancer: a meta-analysis of observational studies.

Author information

1
Department of Ophthalmology, Affiliated Zhejiang Provincial People's Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
2
Department of Urology, Affiliated Zhejiang Provincial People's Hospital, School of Medicine, Zhejiang University, Shangtang Road 158, Hangzhou, 310014, Zhejiang Province, People's Republic of China. zjuwangs@gmail.com.
3
Department of Urology, Affiliated Zhejiang Provincial People's Hospital, School of Medicine, Zhejiang University, Shangtang Road 158, Hangzhou, 310014, Zhejiang Province, People's Republic of China.

Abstract

BACKGROUND:

Epidemiologic studies have reported various results relating phytoestrogens to prostate cancer (PCa). The aim of this study was to provide a comprehensive meta-analysis on the extent of the possible association between phytoestrogens (including consumption and serum concentration) and the risk of PCa.

METHODS:

Eligible studies were retrieved via both computer searches and review of references. The summary relative risk ratio (RR) or odds ratio (OR) and 95% confidence interval (CI) were calculated with random effects models.

RESULTS:

A total of 11 studies (2 cohort and 9 case-control studies) on phytoestrogen intake and 8 studies on serum concentration were included in the meta-analysis. The pooled odds ratio (OR) showed a significant influence of the highest phytoestrogens consumption (OR 0.80, 95% CI 0.70-0.91) and serum concentration (OR 0.83, 95% CI 0.70-0.99) on the risk of PCa. In stratified analysis, high genistein and daidzein intake and increased serum concentration of enterolactone were associated with a significant reduced risk of PCa. However, no significant associations were observed for isoflavone intake, lignans intake, or serum concentrations of genistein, daidzein, or equol.

CONCLUSIONS:

The overall current literature suggests that phytoestrogen intake is associated with a decreased risk of PCa, especially genistein and daidzein intake. Increased serum concentration of enterolactone was also associated with a significant reduced risk of PCa. Further efforts should be made to clarify the underlying biological mechanisms.

PMID:
26228387
PMCID:
PMC4521376
DOI:
10.1186/s12957-015-0648-9
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center