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Sci Rep. 2015 Jul 31;5:12770. doi: 10.1038/srep12770.

γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial.

Author information

1
Institute for Psychological Research, Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands.
2
Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Germany.

Abstract

In order to accomplish a task goal, real-life environments require us to develop different action control strategies in order to rapidly react to fast-moving visual and auditory stimuli. When engaging in complex scenarios, it is essential to prioritise and cascade different actions. Recent studies have pointed to an important role of the gamma-aminobutyric acid (GABA)-ergic system in the neuromodulation of action cascading. In this study we assessed the specific causal role of the GABA-ergic system in modulating the efficiency of action cascading by administering 800 mg of synthetic GABA or 800 mg oral of microcrystalline cellulose (placebo). In a double-blind, randomised, between-group design, 30 healthy adults performed a stop-change paradigm. Results showed that the administration of GABA, compared to placebo, increased action selection when an interruption (stop) and a change towards an alternative response were required simultaneously, and when such a change had to occur after the completion of the stop process. These findings, involving the systemic administration of synthetic GABA, provide the first evidence for a possible causal role of the GABA-ergic system in modulating performance in action cascading.

PMID:
26227783
PMCID:
PMC4521208
DOI:
10.1038/srep12770
[Indexed for MEDLINE]
Free PMC Article

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