Format

Send to

Choose Destination
Eur J Pediatr. 2016 Jan;175(1):131-5. doi: 10.1007/s00431-015-2597-2. Epub 2015 Jul 31.

Riboflavin in cyclic vomiting syndrome: efficacy in three children.

Author information

1
Pediatric Neurology, Child and Adolescent Department, Geneva University Hospitals, Geneva, Switzerland. anastasia.martinez-e.melnikova@outlook.com.
2
Pediatric Gastroenterology, Grangettes Clinic, Geneva, Switzerland. michela.tempia@grangettes.ch.
3
Pediatric Neurology, Child and Adolescent Department, Geneva University Hospitals, Geneva, Switzerland. Christian.Korff@hcuge.ch.

Abstract

Cyclic vomiting syndrome is an episodic disorder considered to be a migraine variant. Riboflavin is efficient in the prophylactic treatment of migraines in adults. We describe the effectiveness and tolerance of riboflavin treatment in three children with cyclic vomiting syndrome. All of them fulfilled the diagnosis criteria for cyclic vomiting syndrome. They received prophylactic monotherapy with riboflavin for at least 12 months. Excellent response and tolerability was observed.

CONCLUSION:

Based on clinical observation in three cases, riboflavin may be an effective and safe prophylactic treatment for children with cyclic vomiting syndrome.

WHAT IS KNOWN:

CVS is one of the "childhood periodic syndromes" classified as a migraine subtype by the International Headache Society. Riboflavin is currently used as a prophylactic treatment in patients with migraine.

WHAT IS NEW:

Riboflavin may be an effective and safe prophylactic treatment for children with CVS. Increasing doses of riboflavin and long periods of prophylaxis may be needed in some children..

KEYWORDS:

Children; Cyclic vomiting syndrome; Migraine; Periodic syndromes; Riboflavin

PMID:
26226892
DOI:
10.1007/s00431-015-2597-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center