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Curr Opin Microbiol. 2015 Aug;26:116-22. doi: 10.1016/j.mib.2015.07.001. Epub 2015 Jul 28.

Life as a moving fluid: fate of cytoplasmic macromolecules in dynamic fungal syncytia.

Author information

1
Departments of Mathematics and Biomathematics, University of California, Los Angeles, CA 90095, United States. Electronic address: mroper@math.ucla.edu.
2
Department of Biochemistry and Howard Hughes Medical Institute, University of Wisconsin-Madison, WI 53706, United States.
3
NIPHT Ltd., Edinburgh EH9 1PL, United Kingdom.
4
Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, United States.

Abstract

In fungal syncytia dozens, or even millions of nuclei may coexist in a single connected cytoplasm. Recent discoveries have exposed some of the adaptations that enable fungi to marshall these nuclei to produce complex coordinated behaviors, including cell growth, nuclear division, secretion and communication. In addition to shedding light on the principles by which syncytia (including embryos and osteoplasts) are organized, fungal adaptations for dealing with internal genetic diversity and physically dynamic cytoplasm may provide mechanistic insights into how cells generally are carved into different functional compartments. In this review we focus on enumerating the physical constraints associated with maintaining macromolecular distributions within a fluctuating and often flowing cytoplasmic interior.

PMID:
26226449
PMCID:
PMC4577449
DOI:
10.1016/j.mib.2015.07.001
[Indexed for MEDLINE]
Free PMC Article

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