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J Perinatol. 2015 Oct;35(10):813-7. doi: 10.1038/jp.2015.88. Epub 2015 Jul 30.

Maternal/neonatal vitamin D deficiency: a risk factor for bronchopulmonary dysplasia in preterms?

Author information

1
Kanuni Sultan Suleyman Teaching and Research Hospital, Department of Neonatology, Istanbul, Turkey.
2
Gulhane Military Medical Faculty, Department of Neonatology, Istanbul, Turkey.
3
Kanuni Sultan Suleyman Teaching and Research Hospital, Department of Pediatrics, Istanbul, Turkey.
4
Gulhane Military Medical Faculty, Department of Pediatrics, Istanbul, Turkey.
5
Gulhane Military Medical Faculty, Department of Biochemistry, Ankara, Turkey.

Abstract

OBJECTIVE:

The objective of this study was to investigate the possible association between maternal/neonatal 25-hydroxy vitamin D (25-OHD) levels and development of bronchopulmonary dysplasia.

STUDY DESIGN:

One hundred and thirty-two preterm infants ⩽32 weeks of gestation who were diagnosed with respiratory distress syndrome were enrolled. 25-OHD levels were determined in maternal/neonatal blood samples that were obtained at the time of admission to the neonatal intensive care unit.

RESULT:

A total of 100 infants were included and 31 (31%) developed bronchopulmonary dysplasia (BPD). Both maternal and neonatal 25-OHD levels in the BPD group were significantly lower compared with those in the no-BPD group (P=0.0001). A positive correlation was detected between maternal and neonatal 25-OHD levels. All of the infants with BPD had a 25-OHD level <10 ng ml(-1), which represented severe deficiency. Univariate logistic regression analysis revealed that maternal/neonatal vitamin D levels were a significant predictor of BPD (odds ratio (OR): 0.76 and 0.61, respectively, P<0.001).

CONCLUSION:

We demonstrated for the first time that lower maternal and neonatal vitamin 25-OHD levels were associated with BPD development in preterm infants. However, further studies with larger sample sizes are needed to delineate the possible link between vitamin D deficiency and BPD.

PMID:
26226242
DOI:
10.1038/jp.2015.88
[Indexed for MEDLINE]

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