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Molecules. 2015 Jul 28;20(8):13725-39. doi: 10.3390/molecules200813725.

Phenolic Compounds from the Roots of Rhodiola crenulata and Their Antioxidant and Inducing IFN-γ Production Activities.

Author information

1
Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. zjt19881206@126.com.
2
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China. zjt19881206@126.com.
3
Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China. lichenyangchina@163.com.
4
Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. pharmwch@126.com.
5
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China. pharmwch@126.com.
6
Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. 13516185421@139.com.
7
Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China. wangxiaodong@szu.edu.cn.
8
Shijiazhuang Yiling Pharmaceutical Co., Ltd, Shijiazhuang 050035, China. wht72007@126.com.
9
Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. yanzhu.harvard@gmail.com.
10
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China. yanzhu.harvard@gmail.com.
11
Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. miaomiaojiang@126.com.
12
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China. miaomiaojiang@126.com.
13
Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. gaoxiumei@tjutcm.edu.cn.

Abstract

In the present study, two new phenolic compounds 1 and 11, a pair of lignan isomers 12 and 13 with their absolute configurations established for the first time, were isolated from the ethanol extract of the roots of Rhodiola crenulata, together with 13 known phenolic compounds, and their structures were elucidated via NMR, HRESIMS, UV, IR and CD analyses. All the isolated compounds were evaluated for their in vitro antioxidant activities using the 2,2-diphenyl-1-picryhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assays. Ten of them exhibited significant antioxidant activities compared to ascorbic acid. Furthermore, the inducibilities of the isolated compounds to IFN-γ production were also assessed. Compounds 1, 8, 9, 12, 13, 14 and 15 could moderately stimulate IFN-γ expression.

KEYWORDS:

IFN-γ production; Rhodiola crenulata; antioxidant activity; immunomodulatory effect; phenol

PMID:
26225952
PMCID:
PMC6332023
DOI:
10.3390/molecules200813725
[Indexed for MEDLINE]
Free PMC Article

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