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Ann Biomed Eng. 2015 Oct;43(10):2314-33. doi: 10.1007/s10439-015-1394-4. Epub 2015 Jul 30.

Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies.

Author information

1
Department of Biomedical Engineering, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2410 Engineering Hall, Irvine, CA, 92697-2730, USA. arashkh@uci.edu.
2
Department of Medicine, Division of Cardiology, University of California, Irvine School of Medicine, Irvine, CA, USA. arashkh@uci.edu.
3
Department of Biomedical Engineering, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2410 Engineering Hall, Irvine, CA, 92697-2730, USA.
4
Department of Medicine, Division of Cardiology, University of California, Irvine School of Medicine, Irvine, CA, USA.
5
Department of Bioengineering and Mechanical Engineering, University of California, Berkeley, CA, USA.
6
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
7
Department of Mechanical Engineering, School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.
8
Department of Mechanical & Industrial Engineering, University of Toronto, Toronto, ON, Canada.
9
Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
10
Department of Bioengineering, Rice University, Houston, TX, USA.
11
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
12
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
13
Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA.
14
Department of Mathematics, University of Houston, Houston, TX, USA.
15
Department of Mathematics, Center for Interdisciplinary Applied Mathematics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
16
McAllister Heart Institute, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Abstract

In this final portion of an extensive review of heart valve engineering, we focus on the computational methods and experimental studies related to heart valves. The discussion begins with a thorough review of computational modeling and the governing equations of fluid and structural interaction. We then move onto multiscale and disease specific modeling. Finally, advanced methods related to in vitro testing of the heart valves are reviewed. This section of the review series is intended to illustrate application of computational methods and experimental studies and their interrelation for studying heart valves.

KEYWORDS:

Biaxial testing; Computational modeling; Heart valves; Multiscale modeling; Numerical simulation; Particle image velocimetry

PMID:
26224522
DOI:
10.1007/s10439-015-1394-4
[Indexed for MEDLINE]

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