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J Virol. 2015 Oct;89(20):10688-92. doi: 10.1128/JVI.01842-15. Epub 2015 Jul 29.

R5 Macrophage-Tropic HIV-1 in the Male Genital Tract.

Author information

1
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
2
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
3
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
4
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA risunc@med.unc.edu.

Abstract

The entry tropism of HIV-1 Env proteins from virus isolated from the blood and genital tract of five men with compartmentalized lineages was determined. The Env proteins isolated from the genital tract of subject C018 were macrophage-tropic proteins, while the remaining cloned env genes encoded R5 T cell-tropic proteins. The detection of a macrophage-tropic lineage of HIV-1 within the male genital tract strongly suggests that evolution of macrophage-tropic viruses can occur in anatomically isolated sites outside the central nervous system.

PMID:
26223642
PMCID:
PMC4580182
DOI:
10.1128/JVI.01842-15
[Indexed for MEDLINE]
Free PMC Article

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