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Atherosclerosis. 2015 Sep;242(1):222-5. doi: 10.1016/j.atherosclerosis.2015.07.031. Epub 2015 Jul 17.

The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study.

Author information

1
Dept. of Clinical Immunology, Aarhus University Hospital, Aarhus N, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: khoa89dinh@gmail.com.
2
Dept. of Clinical Immunology, Naestved Hospital, Naestved, Ringstedgade 61, DK-4700 Naestved, Denmark. Electronic address: olbp@regionsjaelland.dk.
3
Dept. of Clinical Immunology, Aarhus University Hospital, Aarhus N, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: mikkel.petersen@skejby.rm.dk.
4
Dept. of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address: erik.soerensen@regionh.dk.
5
Dept. of Clinical Immunology, Aarhus University Hospital, Aarhus N, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: ceciliejuulsorensen@gmail.com.
6
Dept. of Clinical Immunology, Aarhus University Hospital, Aarhus N, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: kathrinekaspersen@gmail.com.
7
Dept. of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address: Margit.Anita.Hoerup.Larsen@regionh.dk.
8
Dept. of Clinical Immunology, Aarhus University Hospital, Aarhus N, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: bjamoell@rm.dk.
9
Dept. of Epidemiology Research, Statens Serums Institut, Copenhagen S, Artillerivej 5, DK-2300 Copenhagen S, Denmark. Electronic address: HHJ@ssi.dk.
10
Dept. of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address: Henrik.Ullum@regionh.dk.
11
Dept. of Clinical Immunology, Aarhus University Hospital, Aarhus N, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: christian.erikstrup@skejby.rm.dk.

Abstract

BACKGROUND AND PURPOSE:

The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.

METHODS:

Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.

RESULTS:

CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.

CONCLUSION:

In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

KEYWORDS:

Atherosclerosis; CCR5 receptor; Cardiovascular diseases; Epidemiology; Genetics; Inflammation

[Indexed for MEDLINE]

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