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PLoS One. 2015 Jul 29;10(7):e0134028. doi: 10.1371/journal.pone.0134028. eCollection 2015.

Mathematical Modeling of Intravascular Blood Coagulation under Wall Shear Stress.

Author information

1
National Research Center for Hematology, Moscow, Russia; Moscow Institute of Physics and Technology, Dolgoprudny, Russia; Cherkasy National University, Cherkasy, Ukraine.
2
Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
3
National Research Center for Hematology, Moscow, Russia.
4
National Research Center for Hematology, Moscow, Russia; Moscow Institute of Physics and Technology, Dolgoprudny, Russia.

Abstract

Increased shear stress such as observed at local stenosis may cause drastic changes in the permeability of the vessel wall to procoagulants and thus initiate intravascular blood coagulation. In this paper we suggest a mathematical model to investigate how shear stress-induced permeability influences the thrombogenic potential of atherosclerotic plaques. Numerical analysis of the model reveals the existence of two hydrodynamic thresholds for activation of blood coagulation in the system and unveils typical scenarios of thrombus formation. The dependence of blood coagulation development on the intensity of blood flow, as well as on geometrical parameters of atherosclerotic plaque is described. Relevant parametric diagrams are drawn. The results suggest a previously unrecognized role of relatively small plaques (resulting in less than 50% of the lumen area reduction) in atherothrombosis and have important implications for the existing stenting guidelines.

PMID:
26222505
PMCID:
PMC4519339
DOI:
10.1371/journal.pone.0134028
[Indexed for MEDLINE]
Free PMC Article

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