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Pediatr Infect Dis J. 2015 Nov;34(11):1260-2. doi: 10.1097/INF.0000000000000858.

The Positive Predictive Value of Lyme Elisa for the Diagnosis of Lyme Disease in Children.

Author information

1
From the *Division of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts; †Infectious Diseases Diagnostic Laboratory, Boston Children's Hospital and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts; ‡Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts; and Divisions of §Pediatric Infectious Diseases and ¶General Internal Medicine, Duke University School of Medicine, Durham, North Carolina.

Abstract

By using a Lyme enzyme-linked immunosorbent assay (ELISA), we demonstrated that high ELISA index values are strongly predictive of Lyme disease. In children with clinical presentations consistent with Lyme disease, ELISA index values ≥3.0 had a positive predictive value of 99.4% (95% confidence interval: 98.1-99.8%) for Lyme disease, making a supplemental Western immunoblot potentially unnecessary.

PMID:
26222064
PMCID:
PMC4630803
DOI:
10.1097/INF.0000000000000858
[Indexed for MEDLINE]
Free PMC Article

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