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Autophagy. 2016;12(2):245-60. doi: 10.1080/15548627.2015.1071759. Epub 2015 Jul 29.

Modulation of inflammation by autophagy: Consequences for human disease.

Author information

1
a Department of Internal Medicine , Radboud University Medical Center , Nijmegen , The Netherlands.
2
b Division of Endocrinology, Radboud University Medical Center , Nijmegen , The Netherlands.
3
c Radboud Center for Infectious Diseases, Radboud University Medical Center , Nijmegen , The Netherlands.

Abstract

Autophagy and inflammation are 2 fundamental biological processes involved in both physiological and pathological conditions. Through its crucial role in maintaining cellular homeostasis, autophagy is involved in modulation of cell metabolism, cell survival, and host defense. Defective autophagy is associated with pathological conditions such as cancer, autoimmune disease, neurodegenerative disease, and senescence. Inflammation represents a crucial line of defense against microorganisms and other pathogens, and there is increasing evidence that autophagy has important effects on the induction and modulation of the inflammatory reaction; understanding the balance between these 2 processes may point to important possibilities for therapeutic targeting. This review focuses on the crosstalk between autophagy and inflammation as an emerging field with major implications for understanding the host defense on the one hand, and for the pathogenesis and treatment of immune-mediated diseases on the other hand.

KEYWORDS:

autoimmune diseases; autoinflammatory diseases; autophagy; carcinogenesis; infectious diseases; inflammation

PMID:
26222012
PMCID:
PMC4836004
DOI:
10.1080/15548627.2015.1071759
[Indexed for MEDLINE]
Free PMC Article

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